A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts.

BACKGROUND DNA copy number variants play an important part in the development of common birth defects such as oral clefts. Individual patients with multiple birth defects (including oral clefts) have been shown to carry small and large chromosomal deletions. METHODS We investigated the role of polymorphic copy number deletions by comparing transmission… CONTINUE READING