A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder.

@article{Ewald2005AGS,
  title={A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder.},
  author={Henrik L Ewald and Friedrik Wikman and Beatriz Marcheco Teruel and Henriette N. Buttensch{\"o}n and Manolito Torralba and Thomas D. Als and A El Daoud and Tracey J Flint and Tove Hedegaard Jorgensen and L. Fuente Blanco and Torben Arvid Kruse and Torben Falck Orntoft and Ole Mors},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2005},
  volume={133B 1},
  pages={25-30}
}
Homozygosity mapping is a very powerful method for finding rare recessive disease genes in monogenic disorders and may also be useful for locating risk genes in complex disorders, late onset disorders where parents often are not available, and for rare phenotypic subgroups. In the present study, homozygosity mapping was applied to 24 persons with bipolar disorder from 22 inbred families. The families were selected irrespective of whether other affected family members were present or not. A… CONTINUE READING

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