A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.

@article{Coon1993AGS,
  title={A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.},
  author={Hilary Coon and Stefan Jensen and M. Hoff and John Holik and Rosemarie Plaetke and Fred W. Reimherr and Paul Wender and M. Leppert and William Byerley},
  journal={American journal of human genetics},
  year={1993},
  volume={52 6},
  pages={1234-49}
}
Manic-depressive illness (MDI), also known as "bipolar affective disorder," is a common and devastating neuropsychiatric illness. Although pivotal biochemical alterations underlying the disease are unknown, results of family, twin, and adoption studies consistently implicate genetic transmission in the pathogenesis of MDI. In order to carry out linkage analysis, we ascertained eight moderately sized pedigrees containing multiple cases of the disease. For a four-allele marker mapping 5 cM from… CONTINUE READING
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