A genome-wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3.

@article{Kurz2005AGS,
  title={A genome-wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3.},
  author={Thorsten Kurz and Janine Altmueller and Konstantin Strauch and Franz R{\"u}schendorf and Andrea Heinzmann and Miriam F Moffatt and W. O. C. Cookson and Filipe In{\'a}cio and Peter N{\"u}rnberg and Hans H Stassen and Klaus A. Deichmann},
  journal={Allergy},
  year={2005},
  volume={60 2},
  pages={192-9}
}
BACKGROUND Dissecting complex diseases in underlying distinct traits and studying these for their genetic basis might enhance the power as well as the specificity, of detection of disease genes. These phenotypes are known as intermediate phenotypes. OBJECTIVE We were interested in the atopic basis of asthma, and used the sensitization to mite (Dermatophagoides pteronyssinus) allergens as a pathophysiologically important intermediate phenotype. METHODS This time we performed a genome-wide… CONTINUE READING