A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity.

  title={A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity.},
  author={Xue Zhou and Adriana G Arita and Thomas P Ellen and Xin Liu and Jingxiang Bai and John Paul Rooney and Adrienne D Kurtz and Catherine B. Klein and Wei Dai and Thomas J. Begley and Max Costa},
  volume={94 5},
We have used Saccharomyces cerevisiae to identify toxicologically important proteins and pathways involved in arsenic-induced toxicity and carcinogenicity in humans. We performed a systemic screen of the complete set of 4733 haploid S. cerevisiae single-gene-deletion mutants to identify those that have decreased or increased growth, relative to wild type, after exposure to sodium arsenite (NaAsO(2)). IC(50) values for all mutants were determined to further validate our results. Ultimately we… CONTINUE READING
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