A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study.

@article{Meigs2002AGS,
  title={A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study.},
  author={James B. Meigs and Carolien I. M. Panhuysen and Richard H. Myers and Peter W. F. Wilson and L. Adrienne Cupples},
  journal={Diabetes},
  year={2002},
  volume={51 3},
  pages={833-40}
}
Elevated blood glucose levels are the hallmark of type 2 diabetes as well as a powerful risk factor for development of the disease. We conducted a genome-wide search for diabetes-related genes, using measures of glycemia as quantitative traits in 330 pedigrees from the Framingham Heart Study. Of 3,799 attendees at the 5th Offspring Study exam cycle (1991--1995), 1,461, 1,251, and 771 men (49%) and women provided information on levels of 20-year mean fasting glucose, current fasting glucose, and… CONTINUE READING
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