A genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms

@article{Zhou2020AGM,
  title={A genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms},
  author={L. Zhou and Caitlyn A. Miller and L. Miraglia and Angelica Romero and L. S. Mure and S. Panda and S. Kay},
  journal={Proceedings of the National Academy of Sciences},
  year={2020},
  volume={118}
}
Significance Although miRNAs are emerging as important regulators of diverse physiological and pathological processes, our knowledge of their potential role in regulation of circadian rhythms is still limited. We deployed a cell-based genome-wide screening approach and successfully identified mature miRNAs as cell-autonomous circadian modulators. We then specifically focused on the miR-183/96/182 cluster among the candidate miRNA hits and revealed their circadian function both in vitro and in… Expand