A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.

@article{Ramasamy2011AGM,
  title={A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.},
  author={Adaikalavan Ramasamy and Ivan Curjuric and Lachlan J. Coin and Ashish Kumar and Wendy L McArdle and Medea Imboden and B{\'e}n{\'e}dicte Leynaert and Manolis Kogevinas and Peter Schmid‐Grendelmeier and Juha Pekkanen and Matthias Wjst and Andreas J. Bircher and Ulla Sovio and Thierry Rochat and A-L. Hartikainen and David J. Balding and Marjo-Riitta Jarvelin and Nicole Probst-Hensch and David P. Strachan and Deborah L. Jarvis},
  journal={The Journal of allergy and clinical immunology},
  year={2011},
  volume={128 5},
  pages={
          996-1005
        }
}
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Genetic risk factors for the development of allergic disease identified by genome-wide association
  • M. Portelli, E. Hodge, I. Sayers
  • Biology, Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2015
TLDR
Genes involved in both adaptive and innate immune mechanisms have been identified, notably including multiple genes involved in epithelial function/secretion, suggesting that the airway epithelium may be particularly important in asthma.
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
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