A genome-wide family-based linkage study of coeliac disease.

@article{King2000AGF,
  title={A genome-wide family-based linkage study of coeliac disease.},
  author={Alistair L. King and J. Y. Yiannakou and Peter M. Brett and David Curtis and Michael Aug. Morris and Andrew Martin Dearlove and Matthew Rhodes and Sandra Rosen-Bronson and Cherian Mathew and Heather Julia Ellis and Paul Jonathan Ciclitira},
  journal={Annals of human genetics},
  year={2000},
  volume={64 Pt 6},
  pages={
          479-90
        }
}
The susceptibility to develop coeliac disease (CD) has a strong genetic component, which is not entirely explained by HLA associations. Two previous genome wide linkage studies have been performed to identify additional loci outside this region. These studies both used a sib-pair design and produced conflicting results. Our aim is to identify non-MHC genetic loci contributing to coeliac disease using a family based linkage study. We performed a genome wide search in 16 highly informative… CONTINUE READING
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