A genome-wide expression analysis in blood identifies pre-elafin as a biomarker in ARDS.

  title={A genome-wide expression analysis in blood identifies pre-elafin as a biomarker in ARDS.},
  author={Zhaoxi Wang and Douglas Beach and Li Su and Rihong Zhai and David C. Christiani},
  journal={American journal of respiratory cell and molecular biology},
  volume={38 6},
Previous microarray-based studies of acute respiratory distress syndrome (ARDS) were performed using various models to mimic disease pathogenesis. The complexity of the pathophysiologic response to direct or indirect lung injury in ARDS is difficult to reconstruct in experimental conditions. Thus, direct analysis of ARDS patient blood may provide valuable information. We investigated genome-wide gene expression profiles in paired whole blood samples from patients with ARDS (n = 8) during the… CONTINUE READING
Highly Cited
This paper has 38 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 23 extracted citations

Using omics approaches to understand pulmonary diseases

Respiratory research • 2017
View 21 Excerpts
Highly Influenced

Biomarkers of ALI/ARDS

View 3 Excerpts
Highly Influenced

Biomarkers in acute lung injury--marking forward progress.

Critical care clinics • 2011
View 4 Excerpts
Highly Influenced

Neutrophil Elastase Inhibitors and Chronic Kidney Disease

International journal of biological sciences • 2018
View 1 Excerpt

Fifty Years of Research in ARDS. Genomic Contributions and Opportunities.

American journal of respiratory and critical care medicine • 2017
View 1 Excerpt

Proteases in Human Diseases

Sajal Chakraborti, Tapati Chakraborti Naranjan S. Dhalla
Springer Singapore • 2017


Publications referenced by this paper.
Showing 1-10 of 52 references

Microarray-based analysis of ventilator-induced lung injury.

Proceedings of the American Thoracic Society • 2007

Functional and genomic changes induced by alveolar transmigration in human neutrophils.

American journal of physiology. Lung cellular and molecular physiology • 2006
View 1 Excerpt

Microarray-based identification of novel biomarkers in asthma.

Allergology international : official journal of the Japanese Society of Allergology • 2006