A genome-wide comparison of recent chimpanzee and human segmental duplications

@article{Cheng2005AGC,
  title={A genome-wide comparison of recent chimpanzee and human segmental duplications},
  author={Z. Cheng and M. Ventura and X. She and P. Khaitovich and T. Graves and K. Osoegawa and D. Church and P. deJong and R. Wilson and S. P{\"a}{\"a}bo and M. Rocchi and Evan E. Eichler},
  journal={Nature},
  year={2005},
  volume={437},
  pages={88-93}
}
  • Z. Cheng, M. Ventura, +9 authors Evan E. Eichler
  • Published 2005
  • Biology, Medicine
  • Nature
  • We present a global comparison of differences in content of segmental duplication between human and chimpanzee, and determine that 33% of human duplications (> 94% sequence identity) are not duplicated in chimpanzee, including some human disease-causing duplications. Combining experimental and computational approaches, we estimate a genomic duplication rate of 4–5 megabases per million years since divergence. These changes have resulted in gene expression differences between the species. In… CONTINUE READING
    375 Citations

    Paper Mentions

    The evolution of human segmental duplications and the core duplicon hypothesis.
    • 55
    • PDF
    A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications.
    • 93
    • PDF
    Understanding the recent evolution of the human genome: insights from human–chimpanzee genome comparisons
    • 87
    • Highly Influenced
    Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee.
    • 62
    • PDF
    Structural divergence between the human and chimpanzee genomes
    • 59
    • Highly Influenced
    Analysis of recent segmental duplications in the bovine genome
    • 80
    • PDF
    Comparative Genomic Analysis of Human and Chimpanzee Indicates a Key Role for Indels in Primate Evolution
    • 60
    • Highly Influenced

    References

    SHOWING 1-10 OF 39 REFERENCES
    Recent Segmental Duplications in the Human Genome
    • 1,269
    Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution
    • 257
    • PDF
    Patterns of segmental duplication in the human genome.
    • 130
    • PDF
    Segmental duplications and copy-number variation in the human genome.
    • 869
    Hotspots of mammalian chromosomal evolution
    • 224