A genome-wide comparison of recent chimpanzee and human segmental duplications

  title={A genome-wide comparison of recent chimpanzee and human segmental duplications},
  author={Z. Cheng and M. Ventura and X. She and P. Khaitovich and T. Graves and K. Osoegawa and D. Church and P. deJong and R. Wilson and S. P{\"a}{\"a}bo and M. Rocchi and Evan E. Eichler},
  • Z. Cheng, M. Ventura, +9 authors Evan E. Eichler
  • Published 2005
  • Biology, Medicine
  • Nature
  • We present a global comparison of differences in content of segmental duplication between human and chimpanzee, and determine that 33% of human duplications (> 94% sequence identity) are not duplicated in chimpanzee, including some human disease-causing duplications. Combining experimental and computational approaches, we estimate a genomic duplication rate of 4–5 megabases per million years since divergence. These changes have resulted in gene expression differences between the species. In… CONTINUE READING
    375 Citations

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