A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.

Abstract

To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-beta and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).

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@article{Broderick2007AGA, title={A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.}, author={Peter Broderick and Luis G. Carvajal-Carmona and Alan M. Pittman and Emily L. Webb and Kimberley M. Howarth and Andrew Rowan and Steven J. Lubbe and Sarah L Spain and Kate Sullivan and Sarah Fielding and Emma E. M. Jaeger and Jayaram Vijayakrishnan and Zoe E Kemp and Maggie Gorman and Ian P Chandler and Elli Papaemmanuil and Steven Penegar and Wendy Wood and Gabrielle S. Sellick and Mobshra Qureshi and Ana F. S. Teixeira and Enric Domingo and Ella Barclay and Lynn Martin and Oliver M. Sieber and David James Kerr and Richard Gray and Julian Peto and Jean-Baptiste Cazier and Ian Tomlinson and Richard S. Houlston}, journal={Nature genetics}, year={2007}, volume={39 11}, pages={1315-7} }