A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

@article{Scott2007AGA,
  title={A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.},
  author={Laura J. Scott and Karen L. Mohlke and Lori L. Bonnycastle and Cristen J. Willer and Yun Li and William Duren and Michael R Erdos and Heather M Stringham and Peter S. Chines and Anne U. Jackson and Ludmila Prokunina-Olsson and Chia-Jen Ding and Amy J. Swift and Narisu Narisu and Tianle Hu and Randall Pruim and Rui Xiao and Xiao-yi Li and Karen N. Conneely and Nancy L Riebow and Andrew G. Sprau and Maurine Tong and Peggy P White and Kurt N. Hetrick and Michael W Barnhart and Craig W Bark and Janet L Goldstein and Lee Watkins and Fang Xiang and Jouko Saramies and Thomas A. Buchanan and Richard M. Watanabe and Timo T. Valle and Leena Kinnunen and Gonçalo R. Abecasis and Elizabeth W. Pugh and Kimberly Doheny and Richard N Bergman and Jaakko Tuomilehto and Francis S. Collins and Michael Boehnke},
  journal={Science},
  year={2007},
  volume={316 5829},
  pages={1341-5}
}
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our… CONTINUE READING
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