A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.

@article{Lee2013AGA,
  title={A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.},
  author={Heon-Jeong Lee and Hyun Goo Woo and Tiffany A. Greenwood and Daniel F Kripke and John Kelsoe},
  journal={Journal of affective disorders},
  year={2013},
  volume={145 2},
  pages={200-7}
}
OBJECTIVE The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. METHOD We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. RESULTS A bipolar case-only… CONTINUE READING
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