A genome-wide association study of global gene expression

@article{Dixon2007AGA,
  title={A genome-wide association study of global gene expression},
  author={Anna L. Dixon and Liming Liang and Miriam F Moffatt and Wei Chen and Simon Heath and Kenny C. C. Wong and Jenny Taylor and Edward C. Burnett and Ivo G Gut and Martin Farrall and G. M. Lathrop and Gonçalo R. Abecasis and William O. C. M. Cookson},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={1202-1207}
}
We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma. We genotyped 408,273 SNPs and identified expression quantitative trait loci from measurements of 54,675 transcripts representing 20,599 genes in Epstein-Barr virus–transformed lymphoblastoid cell lines. We found that 15,084 transcripts (28%) representing 6,660 genes had narrow-sense heritabilities (H2) > 0.3. We executed genome-wide association… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 333 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 449 citations

334 Citations

02040'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 334 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 24 references

A genome-wide association study identifies novel risk loci for type 2 diabetes

  • R Sladek
  • Nature 445,
  • 2007

Genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma

  • Moffatt, M.F
  • Nature 448,
  • 2007
1 Excerpt

Intergenic variants of HBS1L-MYB are responsible for a major QTL on chromosome 6q23 influencing HbF levels in adults

  • Thein, S.L
  • Proc. Natl. Acad. Sci. USA 104,
  • 2007

Relative impact of nucleotide and copy number variation on gene expression phenotypes

  • Stranger, B.E
  • Science 315,
  • 2007