A genome-wide association study of depressive symptoms.

  title={A genome-wide association study of depressive symptoms.},
  author={Karin Hek and Ayşe Demirkan and Jari Lahti and A. Terracciano and Alexander Teumer and M C Cornelis and Najaf Amin and Erin Bakshis and Jens Baumert and Jingzhong Ding and Yongmei Liu and Kristin D. Marciante and Os{\'o}rio C Meirelles and Michael A. Nalls and Yan V. Sun and Nicole Vogelzangs and Lei Yu and Stefania Bandinelli and Emelia J Benjamin and David A. Bennett and Dorret I. Boomsma and Alessandra Cannas and Laura H. Coker and Eco J. C. de Geus and Philip L De Jager and Ana V. Diez-Roux and Shaun M Purcell and Frank B Hu and Eric B Rimma and David J. Hunter and Majken Karoline Jensen and Gary C. Curhan and Kenneth M Rice and Alan D. Penman and Jerome I. Rotter and Nona Sotoodehnia and Rebecca T Emeny and Johan G Eriksson and Denis A. Evans and Luigi Ferrucci and Myriam Fornage and Vilmundur Gudnason and Albert Hofman and Thomas Illig and Sharon L. R. Kardia and Margaret Kelly-Hayes and Karestan Koenen and Peter Kraft and Maris Kuningas and Joseph M. Massaro and David Melzer and Antonella Mulas and Cornelis Lambert Mulder and Anna Murray and Ben A. Oostra and Aarno V Palotie and Brenda P. Penninx and Astrid Petersmann and Luke C Pilling and Bruce M. Psaty and Rajesh Rawal and Eric M. Reiman and Andrea Schulz and Joshua M Shulman and Andrew Singleton and Albert Vernon Smith and Angelina R Sutin and Andr{\'e} G. Uitterlinden and Henry V{\"o}lzke and Elisabeth I M Widen and Kristine Yaffe and Alan B. Zonderman and Francesco Cucca and Tamara B. Harris and K H Ladwig and David J. Llewellyn and Katri R{\"a}ikk{\"o}nen and Toshiko Tanaka and Cornelia M van Duijn and Hans J{\"o}rgen Grabe and Lenore J. Launer and Kathryn L. Lunetta and Thomas H. Mosley and Anne B. Newman and Henning Tiemeier and Joanne M. Murabito},
  journal={Biological psychiatry},
  volume={73 7},
BACKGROUND Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms. METHODS In this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of… CONTINUE READING
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