A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

@article{Peden2011AGA,
  title={A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease},
  author={John F. Peden and Martin Farrall and Hugh C. Watkins and Anuj Goel and Halit Ongen and Anna Helgad{\'o}ttir and Shapour Jalilzadeh and Theodosios Kyriakou and Peter Sleight and Jemma C. Hopewell and Rory Collins and Sarah Parish and Robert J. Clarke and Alison Offer and Louise Bowman and Jane Armitage and Richard Peto and Pamela Linksted and Derrick A Bennett and Danish Saleheen and Asif Rasheed and Moazzam Ali Zaidi and Nabi Shah and Maria Samuel and P. M. Frossard and John Danesh and John C Chambers and Paul Elliott and Weihua Zhang and Jaspal S Kooner and J{\"o}rg Hager and Mark G. Lathrop and Simon C. Heath and Marcel Delepine and Nicole Soranzo and Kathleen E. Stirrups and Panos Deloukas and Muhammed Murtaza and Leena Peltonen and Anders Hamsten and Rona J. Strawbridge and Anders Malarstig and John {\"O}hrvik and Lasse Folkersen and Per Eriksson and Angela Silveira and Van 'T Hooft Fm and James G. Scott and Joban S. Sehmi and Simon C. Potter and Sarah E. Hunt and Rhian Gwilliam and Sue J Bumpstead and Elizabeth E Gray and Sarah Edkins and Tomas Axelsson and Ann-Christine Elizabet Syvanen and Anders Franco‐Cereceda and Anders Gabrielsen and Udo Seedorf and Stephan Rust and Gerd Assmann and Gonçalo R. Abecasis and Naveeduddin Ahmed and Angad S Kooner and Mark J. Caulfield and Peter Donnelly and Mark I. McCarthy and Philippe Froguel and Nilesh J. Samani and M-L Hell{\'a}nius and Gunnar Olsson and Simona Barlera and Gianni Tognoni and Maria Grazia Franzosi and Silvia Pietri and Francesca Gori and Fiona R. Green and Nadeem H. Mallick and Muhammad Tehseen Azhar and Khan Shah Zaman and Abdus Samad and Mohammad Ishaq and Ali Raza Gardezi and Fozia Memon and Tim D. Spector and Nieminen and Juha P. Sinisalo and Salomaa and Samuli Ripatti and Karin Leander and Bruna Gigante and U Defaire and Roberto Marchioli and Suthesh Sivapalaratnam and Jjp Kastelein and Trip and Eirini Theodoraki and George V. Dedoussis and Jc Engert and Salim Yusuf and Sonia S Anand},
  journal={Nature Genetics},
  year={2011},
  volume={43},
  pages={339-344}
}
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD), a modest number considering the apparent heritability of CAD. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls… 
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