A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

  title={A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia},
  author={Maria C. Bernardo and Dalemari Crowther-Swanepoel and Peter Broderick and Emily C Webb and Gabrielle S. Sellick and Ruth W Wild and Kate Sullivan and Jayaram Vijayakrishnan and Yufei Wang and Alan M. Pittman and Nicola J. Sunter and Andrew G Hall and Martin J. S. Dyer and Estella Matutes and Claire E. Dearden and Tryfonia Mainou-Fowler and Graham Hunter Jackson and Geoffrey P. Summerfield and Robert J. Harris and Andrew R. Pettitt and Peter Hillmen and David J Allsup and James R. Bailey and Guy Pratt and Chris Pepper and Christopher Fegan and James M. Allan and Daniel Catovsky and Richard S. Houlston},
  journal={Nature Genetics},
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 × 10−10), 2q37.1 (rs13397985, SP140; P = 5.40 × 10−10), 6p25.3 (rs872071, IRF4; P = 1.91 × 10−20), 11q24.1 (rs735665; P = 3.78 × 10−12), 15q23 (rs7176508; P = 4.54 × 10−12) and 19q13.32 (rs11083846, PRKD2; P = 3.96… CONTINUE READING


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