A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

Abstract

Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African… (More)
DOI: 10.1186/s12863-015-0299-4

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@article{Lutz2015AGA, title={A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry}, author={Sharon M. Lutz and Michael H. Cho and Kendra A. Young and Craig P. Hersh and Peter J. Castaldi and Merry-Lynn N McDonald and Elizabeth A. Regan and Manuel Mattheisen and Dawn L. DeMeo and Margaret M. Parker and Marilyn G. Foreman and Barry J. Make and Robert Leroy Jensen and Richard H Casaburi and David A. Lomas and Surya Prakash Bhatt and Per S. Bakke and Amund Gulsvik and James D. Crapo and Terri H. Beaty and Nan M. Laird and Christoph Lange and John E. Hokanson and Edwin K. Silverman}, journal={BMC Genetics}, year={2015}, volume={16}, pages={1-11} }