A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor

@article{Chung2010AGA,
  title={A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor},
  author={Chan-Moon Chung and R-Y Wang and Jian-Wen Chen and Cathy S. J. Fann and H-B Leu and H-Y Ho and C-T Ting and T-h Lin and S-H Sheu and Wen-Chen Tsai and J-H Chen and Y-S Jong and S-J Lin and Y T Chen and Wen-Harn Pan},
  journal={The Pharmacogenomics Journal},
  year={2010},
  volume={10},
  pages={537-544}
}
Because angiotensin-converting enzyme (ACE) activity is implicated widely in biological systems, we aimed to identify its novel quantitative trait loci for the purposes of understanding ACE activity regulation and pharmacogenetics relating to ACE inhibitor (ACEI). We performed a two-stage genome-wide association study: (1) from 400 young-onset hypertension (YOH) subjects and (2) a confirmation study with an additional 623 YOH subjects. In the first stage, eight single nucleotide polymorphisms… CONTINUE READING
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