A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

  title={A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33},
  author={G. M. van Petersen and Laufey T Amundadottir and Charles S. Fuchs and Peter Kraft and Rachael Z. Stolzenberg-Solomon and Kevin Bruce Jacobs and Alan A. Arslan and Hendrik Bas Bueno-de-Mesquita and Steven Gallinger and Myron D. Gross and Kathy J. Helzlsouer and Elizabeth Holly and Eric J Jacobs and Alison P Klein and Andrea Z LaCroix and Dong-hui Li and Margaret T. Mandelson and Sara H. Olson and Harvey A. Risch and Wei Zheng and Demetrius Albanes and William R. Bamlet and Cornelis van den Berg and Marie-Christine Boutron-Ruault and Julie E. Buring and Paige Marie Bracci and Frederico Canzian and Sandra C Clipp and Michelle Cotterchio and Mariza de Andrade and Eric J Duell and J. Michael Gaziano and Edward L. Giovannucci and Michael G Goggins and Göran Hallmans and Susan E. Hankinson and Manal Ismaeel Hassan and Barbara V Howard and David J. Hunter and Amy K Hutchinson and Seyyed Mehdi Hosseini Jenab and Rudolf Kaaks and Charles Kooperberg and Vittorio Krogh and Robert C. Kurtz and Shannon M. Lynch and Robert R McWilliams and Julie Bloch Mendelsohn and Dominique S. Michaud and Hemang Parikh and Alpa V. Patel and Petra H. M. Peeters and Aleksandar Rajkovic and E. Berti Riboli and L. Pi{\~n}eiro Rodr{\'i}guez and Daniela Seminara and Xiao-Ou Shu and George K. Thomas and Anne Tj{\o}nneland and Geoffrey S. Tobias and Dimitirios Trichopoulos and Stephen Van Den Eeden and Jarmo R Virtamo and Jean Wactawski-Wende and Zhaoming Wang and Brian Wolpin and Herbert Yu and Kai Yu and Anne Zeleniuch-Jacquotte and JosephF. Fraumeni and Robert Nathaniel Hoover and Patricia A Hartge and Stephen J. Chanock},
  journal={Nature Genetics},
We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 × 10… CONTINUE READING

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