A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

@article{Hunter2007AGA,
  title={A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer},
  author={David J. Hunter and Peter Kraft and Kevin B. Jacobs and David G. Cox and Meredith Yeager and Susan E. Hankinson and Sholom Wacholder and Zhaoming Wang and Robert Welch and Amy Hutchinson and Junwen Wang and Kai Yu and Nilanjan Chatterjee and Nick Orr and Walter C Willett and Graham A. Colditz and Regina G Ziegler and C. T. van den Berg and Saundra S. Buys and Catherine A. McCarty and Heather Spencer Feigelson and Eugenia E. Calle and Michael J. Thun and Richard B Hayes and Margaret Tucker and Daniela S. Gerhard and Joseph F. Jr. Fraumeni and Robert Nathaniel Hoover and Gilles Thomas and Stephen J. Chanock},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={870-874}
}
We conducted a genome-wide association study (GWAS) of breast cancer by genotyping 528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls. We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies… CONTINUE READING
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