A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

@article{Hunter2007AGA,
  title={A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer},
  author={D. Hunter and P. Kraft and K. Jacobs and D. Cox and M. Yeager and S. Hankinson and S. Wacholder and Z. Wang and R. Welch and A. Hutchinson and Junwen Wang and K. Yu and N. Chatterjee and N. Orr and W. Willett and G. Colditz and R. Ziegler and C. Berg and S. Buys and C. McCarty and H. Feigelson and E. Calle and M. Thun and R. Hayes and M. Tucker and D. Gerhard and J. Fraumeni and R. Hoover and G. Thomas and S. Chanock},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={870-874}
}
We conducted a genome-wide association study (GWAS) of breast cancer by genotyping 528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls. We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies… Expand

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References

SHOWING 1-10 OF 31 REFERENCES
Genome-wide association study identifies novel breast cancer susceptibility loci
TLDR
To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation. Expand
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
TLDR
Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295. Expand
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
TLDR
A second genetic variant in the 8q24 region that, in conjunction with another variant recently discovered, accounts for about 11%–13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans is reported. Expand
A genome-wide association study identifies novel risk loci for type 2 diabetes
TLDR
Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits. Expand
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
TLDR
Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age and for variation in risk by mutation position for both genes, and some evidence for a reduction in risk in women from earlier birth cohorts is found. Expand
Polygenic susceptibility to breast cancer and implications for prevention
TLDR
The results suggest that the construction and use of genetic-risk profiles may provide significant improvements in the efficacy of population-based programs of intervention for cancers and other diseases. Expand
Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada.
TLDR
BRCA1 and BRCA2 mutations may be more frequent in general populations than previously thought and may be associated with various types of cancers. Expand
Association of Polymorphisms in the Paraoxonase 1 Gene with Breast Cancer Incidence in the CPS-II Nutrition Cohort
TLDR
The results suggest that genetic variation in PON1, particularly at the L55M SNP, may be associated with increased risk of breast cancer in postmenopausal women, and NSAID use seems to modify this risk. Expand
A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer.
TLDR
Data from the Nurses' Health Study and a pooled analysis of three studies indicate that prolactin likely is important in breast cancer etiology, particularly ER+ tumors, over a wide range of ages. Expand
Optimal two‐stage genotyping designs for genome‐wide association scans
TLDR
It is shown how existing software for power and sample size calculations can be used for the purpose of designing two‐stage studies, for a wide range of assumptions about the number of markers genotyped and the costs of genotyping in each stage of the study. Expand
...
1
2
3
4
...