A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

  title={A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations},
  author={Klaus B{\o}nnelykke and Patrick M A Sleiman and Kasper Nielsen and Eskil Kreiner-M{\o}ller and Josep Maria Mercader and Danielle Belgrave and Herman T. den Dekker and Anders Husby and Astrid Sevelsted and Grissel Faura-Tellez and Li Juel Mortensen and Lavinia Paternoster and Richard Flaaten and Anne M{\o}lgaard and David E Smart and Philip Francis Thomsen and Morten Arendt Rasmussen and S{\'i}lvia Bon{\`a}s-Guarch and Claus Holst and Ellen Aagaard N{\o}hr and Rachita Yadav and Michael E. March and Thomas Blicher and Peter M. Lackie and Vincent W. V. Jaddoe and Angela Simpson and John W. Holloway and Liesbeth Duijts and Adnan Custovic and Donna E. Davies and David Torrents and Ramneek Gupta and Mads Vilhelm Hollegaard and David Michael Hougaard and Hakon H. Hakonarson and Hans Bisgaard},
  journal={Nature Genetics},
Asthma exacerbations are among the most frequent causes of hospitalization during childhood, but the underlying mechanisms are poorly understood. [] Key Method We performed a genome-wide association study of a specific asthma phenotype characterized by recurrent, severe exacerbations occurring between 2 and 6 years of age in a total of 1,173 cases and 2,522 controls. Cases were identified from national health registries of hospitalization, and DNA was obtained from the Danish Neonatal Screening Biobank. We…
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Genetic association of the functional CDHR3 genotype with early-onset adult asthma in Japanese populations.
  • J. KanazawaH. Masuko N. Hizawa
  • Medicine, Biology
    Allergology international : official journal of the Japanese Society of Allergology
  • 2017
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