A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation.

Abstract

Mammalian target of rapamycin (mTOR) is a giant protein kinase that controls cell proliferation, growth, and metabolism. mTOR is regulated by nutrient availability, by mitogens, and by stress, and operates through two independently regulated hetero-oligomeric complexes. We have attempted to identify the cellular components necessary to maintain the activity… (More)
DOI: 10.1007/978-1-61779-430-8_11

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