A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.

@article{Zubenko1998AGS,
  title={A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.},
  author={George S. Zubenko and Hugh B Hughes and J Scott Stiffler and Mark R. Hurtt and Barry B. Kaplan},
  journal={Genomics},
  year={1998},
  volume={50 2},
  pages={121-8}
}
We completed a systematic survey of the human genome, conducted at an average resolution of 10 cM, for the identification of simple sequence tandem repeat polymorphisms (SSTRPs) that target new risk genes for Alzheimer disease (AD) by virtue of linkage disequilibrium. The efficiency of our association study was enhanced by genotyping pools of DNA from autopsy-confirmed cases with AD and matched controls. Allelic associations with AD were observed for 6 of the 391 SSTRPs in the CHLC Human… CONTINUE READING

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