A genome scan for diabetic nephropathy in African Americans.

  title={A genome scan for diabetic nephropathy in African Americans.},
  author={Donald W. Bowden and Carla J Colicigno and Carl D. Langefeld and Michele M Sale and Adrienne H. Williams and Pamela J Anderson and Stephen S. Rich and Barry I. Freedman},
  journal={Kidney international},
  volume={66 4},
BACKGROUND There is substantial evidence for a genetic contribution to diabetic nephropathy susceptibility in the African American population, but little is known about location or identity of susceptibility genes. METHODS DNA samples were collected from 206 type 2 diabetes (T2DM) and end-stage renal disease (ESRD)/nephropathy-affected sib pairs from 166 African American families (355 affected individuals). A genome scan was performed and data analyzed using nonparametric linkage regression… CONTINUE READING