A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.

@article{Lunardi2010AGP,
  title={A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.},
  author={Andrea Lunardi and Giulio Di Minin and Paolo Provero and Marco Dal Ferro and Marcello Carotti and Giannino Del Sal and Licio Collavin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 14},
  pages={6322-7}
}
The genome of the fruitfly Drosophila melanogaster contains a single p53-like protein, phylogenetically related to the ancestor of the mammalian p53 family of tumor suppressors. We reasoned that a comprehensive map of the protein interaction profile of Drosophila p53 (Dmp53) might help identify conserved interactions of the entire p53 family in man. Using a genome-scale in vitro expression cloning approach, we identified 91 previously unreported Dmp53 interactors, considerably expanding the… CONTINUE READING
Highly Cited
This paper has 56 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Mutant p 53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB 2 IP

Elena Valentinoa, Arianna Bellazzoa, +7 authors Licio Collavina
2017

57 Citations

01020'11'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 57 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…