A genetically humanized mouse model for hepatitis C virus infection

  title={A genetically humanized mouse model for hepatitis C virus infection},
  author={Marcus Dorner and J. A. K. Horwitz and Justin B. Robbins and Walter T. Barry and Qian Feng and Kathy Mu and Christopher Tyler Jones and John W Schoggins and Maria Teresa Catanese and Dennis R. Burton and Mansun Law and Charles M. Rice and Alexander Ploss},
Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially effective and a vaccine does not exist. Development of more effective therapies has been hampered by the lack of a suitable small animal model. Although xenotransplantation of immunodeficient mice with human hepatocytes has shown promise, these models are subject to important challenges. Building on the previous observation that CD81 and occludin comprise the minimal human factors required to render… CONTINUE READING
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