A genetically engineered strain of Saccharopolyspora erythraea that produces 6,12-dideoxyerythromycin A as the major fermentation product

@article{Stassi1998AGE,
  title={A genetically engineered strain of Saccharopolyspora erythraea that produces 6,12-dideoxyerythromycin A as the major fermentation product},
  author={D. Stassi and D. Post and M. Satter and M. Jackson and G. Main{\'e}},
  journal={Applied Microbiology and Biotechnology},
  year={1998},
  volume={49},
  pages={725-731}
}
  • D. Stassi, D. Post, +2 authors G. Mainé
  • Published 1998
  • Medicine, Biology
  • Applied Microbiology and Biotechnology
  • Abstract The erythromycin producer, Saccharopolyspora erythraea ER720, was genetically engineered to produce 6,12-dideoxyerythromycin A, a novel erythromycin derivative, as the major macrolide in the fermentation broth. Inspection of the biosynthetic pathway for erythromycin would suggest that production of this compound could be achieved simply through the disruption of two genes, that encoding the erythromycin C-6 hydroxylase (eryF ) and that encoding the erythromycin C-12 hydroxylase (eryK… CONTINUE READING
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