A genetically engineered attenuated coxsackievirus B3 strain protects mice against lethal infection.

@article{Dan2005AGE,
  title={A genetically engineered attenuated coxsackievirus B3 strain protects mice against lethal infection.},
  author={Meixia Dan and Janet K. Chantler},
  journal={Journal of virology},
  year={2005},
  volume={79 14},
  pages={9285-95}
}
Coxsackievirus B3 (CVB3) is a common human pathogen that is endemic throughout the world. There is currently no vaccine available, although the virus is known to be highly lethal to newborns and has been associated with heart disease and pancreatitis in older children and adults. Previously, we showed that the virulence of CVB3 is reduced by a lysine-to-arginine substitution in the capsid protein VP2 (K2168R) or a glutamic acid-to-glycine substitution in VP3 (E3060G). In this report, we show… CONTINUE READING