A genetically determined murine model of infantile polycystic kidney disease.

@article{Fry1985AGD,
  title={A genetically determined murine model of infantile polycystic kidney disease.},
  author={John L. Fry and William E. Koch and J. Charles Jennette and Elizabeth McFarland and Floyd A. Fried and James Mandell},
  journal={The Journal of urology},
  year={1985},
  volume={134 4},
  pages={
          828-33
        }
}
We have evaluated a congenic strain of mice with congenital polycystic kidney disease in which the disease process appears to closely resemble human infantile polycystic kidney disease. Cysts formed first in the proximal tubules of the nephron and appeared, by light microscopy, to be preceded by vacuolization of the cells. These spaces, as seen by electron microscopy, occurred between adjacent cells. The pancreas was severely involved with reduction of both exocrine and endocrine elements. Cyst… CONTINUE READING

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