A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.

@article{Kiyasova2011AGD,
  title={A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.},
  author={Vera Kiyasova and Sebastian P Fernandez and Jeanne Lain{\'e} and L{\'e}a Stankovski and Aude Muzerelle and St{\'e}phane Doly and Patricia Gaspar},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 8},
  pages={2756-68}
}
Heterogeneity of central serotonin (5-HT) raphe neurons is suggested by numerous lines of evidence, but its genetic basis remains elusive. The transcription factor Pet1 is required for the acquisition of serotonergic identity in a majority of neurons in the raphe nuclei. Nevertheless, a subset of 5-HT neurons differentiates in Pet1 knock-out mice. We show here that these residual 5-HT neurons outline a unique subpopulation of raphe neurons with highly selective anatomical targets and… CONTINUE READING

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