A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

@article{Horikoshi2006AGV,
  title={A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population},
  author={Momoko Horikoshi and Kazuo Hara and Chikako Ito and Ryozo Nagai and Philippe Froguel and Takashi Kadowaki},
  journal={Diabetologia},
  year={2006},
  volume={50},
  pages={747-751}
}
It has been suggested that transcription factor 7-like 2 protein (TCF7L2) plays an important role in glucose metabolism by regulating the production level of glucagon-like peptide-1, a hormone which modifies glucose-dependent insulin secretion. Recently, variants of TCF7L2 gene were reported to confer an increased risk of type 2 diabetes in three different samples from European and European-origin populations. We studied whether the single nucleotide polymorphisms (SNPs) in TCF7L2 were… CONTINUE READING
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