A genetic variant of the serine racemase gene is associated with schizophrenia.

BACKGROUND Serine racemase (SRR) is a brain-enriched enzyme that converts L-serine to D-serine, which acts as an endogenous ligand of N-methyl D-aspartate (NMDA) receptors. Dysfunction of SRR may reduce the function of NMDA receptors and susceptibility to schizophrenia. METHODS We genotyped three single-nucleotide polymorphisms (SNPs) of the 5' region of… (More)