A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity.

@article{Gu2011AGV,
  title={A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity.},
  author={Jian Gu and Yuanqing Ye and Margaret R. Spitz and Jie Lin and Lambertus Alm Kiemeney and Jingliang Xing and Michelle A. T. Hildebrandt and Waun Ki Hong and Christopher I. Amos and Xifeng Wu},
  journal={Human molecular genetics},
  year={2011},
  volume={20 4},
  pages={
          820-6
        }
}
Mutagen sensitivity, a measurement of chromatid breaks induced by various mutagens in short-term cultures of peripheral blood lymphocytes, is an established risk factor for a number of cancers and is highly heritable. The purpose of this study is to identify genetic predictors of mutagen sensitivity. Therefore, we conducted a multi-stage genome-wide association study. The primary scan analyzed 539,437 autosomal SNPs in 673 healthy individuals, followed by validations in two independent sets of… CONTINUE READING

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