A genetic switch for epilepsy in adult mice.

  title={A genetic switch for epilepsy in adult mice.},
  author={Heinz E Krestel and Derya R. Shimshek and Vidar Jensen and Thomas Nevian and Jinhyun Kim and Yu Geng and Thomas Bast and Antoine Depaulis and Kai Schonig and Frieder Schwenk and Hermann Bujard and \Oivind C. Hvalby and Rolf Sprengel and P. H. Seeburg},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 46},
Premature death from seizures afflicts gene-targeted mice expressing the Q/R site-unedited glutamate receptor subunit GluR-B(Q) of AMPA receptors in central neurons. Early seizure-related death has now been circumvented by a genetic switch that restricts GluR-B(Q) expression to forebrain principal neurons from postnatal stages onward, prominently in… CONTINUE READING