A genetic study of bipolar affective disorder.

  title={A genetic study of bipolar affective disorder.},
  author={N W James and Cyril J. Chapman},
  journal={The British journal of psychiatry : the journal of mental science},
A group of 46 bipolar probands and their first degree relatives were studied. A high rate of affective disorder (19.6 per cent) was found, including both unipolar (13.2 percent) and bipolar (6.4 per cent) types, with females predominating (3 : 1). The presence of four fatherson pairs suffering from affective disorder made the hypothesis of X-linked dominance untenable. Results compatible with polygenic inheritance were found, using both Slater's and Falconer's methods. There was no evidence for… CONTINUE READING

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