A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation.

@article{Wangensteen2015AGS,
  title={A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation.},
  author={Kirk J Wangensteen and Sophia Zhang and Linda E. Greenbaum and Klaus H. Kaestner},
  journal={Genes & development},
  year={2015},
  volume={29 9},
  pages={904-9}
}
The fundamental question of which genes are most important in controlling liver regeneration remains unanswered. We employed a parallel screen to test the impact of 43 selected genes on liver repopulation in the Fah(-/-) mouse model of hereditary tyrosinemia. We discovered that the transcription factor Foxa3 was a strong promoter of liver regeneration… CONTINUE READING