A genetic screen in Drosophila for metastatic behavior.

@article{Pagliarini2003AGS,
  title={A genetic screen in Drosophila for metastatic behavior.},
  author={Raymond A Pagliarini and Tian Xu},
  journal={Science},
  year={2003},
  volume={302 5648},
  pages={1227-31}
}
A genetic screen was designed in Drosophila to interrogate its genome for mutations sufficient to cause noninvasive tumors of the eye disc to invade neighboring or distant tissues. We found that cooperation between oncogenic RasV12 expression and inactivation of any one of a number of genes affecting cell polarity leads to metastatic behavior, including basement membrane degradation, loss of E-cadherin expression, migration, invasion, and secondary tumor formation. Inactivation of these cell… CONTINUE READING
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