A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

@article{Voorhoeve2006AGS,
  title={A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.},
  author={Pieter Mathijs Voorhoeve and Carlos le Sage and M. van der Schrier and Ad J. M. Gillis and H. J. Stoop and Remco Nagel and Ying-Poi Liu and Josyanne J A van Duijse and Jarno Drost and Alexander Christiaan Griekspoor and Eitan Zlotorynski and Norikazu Yabuta and Gabriella De Vita and Hiroshi Nojima and Leendert H. J. Looijenga and Reuven Agami},
  journal={Cell},
  year={2006},
  volume={124 6},
  pages={
          1169-81
        }
}
Endogenous small RNAs (miRNAs) regulate gene expression by mechanisms conserved across metazoans. While the number of verified human miRNAs is still expanding, only few have been functionally annotated. To perform genetic screens for novel functions of miRNAs, we developed a library of vectors expressing the majority of cloned human miRNAs and created corresponding DNA barcode arrays. In a screen for miRNAs that cooperate with oncogenes in cellular transformation, we identified miR-372 and miR… CONTINUE READING

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