A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

@article{Mohseni2014AGS,
  title={A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway},
  author={Morvarid Mohseni and Jianlong Sun and Allison N. Lau and Stephen Curtis and Jeffrey Goldsmith and Victor L. Fox and Chongjuan Wei and Marsha Frazier and Owen Samson and Kwok-kin Wong and Carla Y Kim and Fernando D Camargo},
  journal={Nature Cell Biology},
  year={2014},
  volume={16},
  pages={108-117}
}
The Hippo–YAP pathway is an emerging signalling cascade involved in the regulation of stem cell activity and organ size. To identify components of this pathway, we performed an RNAi-based kinome screen in human cells. Our screen identified several kinases not previously associated with Hippo signalling that control multiple cellular processes. One of the hits, LKB1, is a common tumour suppressor whose mechanism of action is only partially understood. We demonstrate that LKB1 acts through its… CONTINUE READING
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