A genetic screen for novel behavioral mutations in mice

@article{Sayah2000AGS,
  title={A genetic screen for novel behavioral mutations in mice},
  author={David M. Sayah and Arshad H. Khan and Timothy Gasperoni and Daniel J Smith},
  journal={Molecular Psychiatry},
  year={2000},
  volume={5},
  pages={369-377}
}
A genetic screen using mice was performed to identify dominant loci affecting behavior. Mice were mutagenized with ENU, then bred to examine their G1 offspring for behavioral abnormalities. Potentially mutant G1 pups were screened through a variety of behavioral assays, including tests of learning and memory, sensorimotor gating, fear and anxiety, nociception (pain perception) and locomotor activity. Mice falling outside the normal performance distribution in these tests were considered… CONTINUE READING

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