A genetic risk factor for periodic limb movements in sleep.

  title={A genetic risk factor for periodic limb movements in sleep.},
  author={Hreinn Stef{\'a}nsson and David B. Rye and Andrew A. Hicks and Hjorvar Petursson and Andr{\'e}s Ingason and Thorgeir E. Thorgeirsson and Stefan Th Palsson and Thordur Sigmundsson and Albert P{\'a}ll Sigurdsson and Ingibjorg Eiriksdottir and Emilia Soebech and Donald L. Bliwise and Joseph M Beck and Ami R. Rosen and Salina P. Waddy and Lynn Marie Trotti and {\'A}lex Iranzo and Madhav Thambisetty and Gudmundur A. Hardarson and Kristleifur Kristj{\'a}nsson and L{\'a}rus J. Gudmundsson and Unnur Thorsteinsd{\'o}ttir and Augustine Kong and Jeffrey R. Gulcher and Daniel Fannar Gudbjartsson and K{\'a}ri Stef{\'a}nsson},
  journal={The New England journal of medicine},
  volume={357 7},
BACKGROUND The restless legs syndrome (RLS) is a common neurologic disorder characterized by an irresistible urge to move the legs. It is a major cause of sleep disruption. Periodic limb movements in sleep are detectable in most patients with RLS and represent an objective physiological metric. METHODS To search for sequence variants contributing to RLS, we performed a genomewide association study and two replication studies. To minimize phenotypic heterogeneity, we focused on patients with… 

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