A genetic risk factor for periodic limb movements in sleep.
@article{Stefnsson2007AGR, title={A genetic risk factor for periodic limb movements in sleep.}, author={Hreinn Stef{\'a}nsson and David B. Rye and Andrew A. Hicks and Hjorvar Petursson and Andr{\'e}s Ingason and Thorgeir E. Thorgeirsson and Stefan Th Palsson and Thordur Sigmundsson and Albert P{\'a}ll Sigurdsson and Ingibjorg Eiriksdottir and Emilia Soebech and Donald L. Bliwise and Joseph M Beck and Ami R. Rosen and Salina P. Waddy and Lynn Marie Trotti and {\'A}lex Iranzo and Madhav Thambisetty and Gudmundur A. Hardarson and Kristleifur Kristj{\'a}nsson and L{\'a}rus J. Gudmundsson and Unnur Thorsteinsd{\'o}ttir and Augustine Kong and Jeffrey R. Gulcher and Daniel Fannar Gudbjartsson and K{\'a}ri Stef{\'a}nsson}, journal={The New England journal of medicine}, year={2007}, volume={357 7}, pages={ 639-47 } }
BACKGROUND
The restless legs syndrome (RLS) is a common neurologic disorder characterized by an irresistible urge to move the legs. It is a major cause of sleep disruption. Periodic limb movements in sleep are detectable in most patients with RLS and represent an objective physiological metric.
METHODS
To search for sequence variants contributing to RLS, we performed a genomewide association study and two replication studies. To minimize phenotypic heterogeneity, we focused on patients with…
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References
SHOWING 1-10 OF 48 REFERENCES
Development of restless legs syndrome after dopaminergic treatment in a patient with periodic leg movements in sleep.
- Medicine, PsychologySleep medicine
- 2003
Periodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatment.
- Psychology, MedicineSleep medicine reviews
- 2006
Prevalence of restless legs syndrome and periodic limb movement disorder in the general population.
- Medicine, PsychologyJournal of psychosomatic research
- 2002
Variable expressivity in familial restless legs syndrome.
- MedicineArchives of neurology
- 1990
It is concluded that there can be variable expressivity of the clinical features in familial restless legs syndrome and that there are probably some relatively nonrestless patients with prominent periodic movements in sleep who are carriers of the restless legs Syndrome gene.
Restless legs syndrome: diagnosis, epidemiology, classification and consequences
- Medicine, PsychologyNeurological Sciences
- 2007
Higher awareness of RLS among physicians is required; it remains an underdiagnosed clinical condition.
Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria
- MedicineMovement disorders : official journal of the Movement Disorder Society
- 1997
A strong relationship was found between these complaints and polysomnographic findings; increasing sleep latency and number of awakenings and decreasing sleep efficiency were associated with worsening symptoms.
Toward a better definition of the restless legs syndrome
- MedicineMovement disorders : official journal of the Movement Disorder Society
- 1995
Features commonly seen in RLS include sleep disturbance, periodic limb movements in sleep and similar involuntary movements while awake, a normal neurological examination in the idiopathic from, a tendency for the symptoms to be worse in middle to older age, and, in some cases, a family history suggestive of an autosomal dominant mode of inheritance.
Restless legs syndrome and periodic limb movement disorder.
- Medicine, PsychologyThe Nursing clinics of North America
- 2002
Restless legs syndrome
- MedicineNeurology
- 1960
Restless legs syndrome is a common cause of insomnia related to problems with sleep initiation and sleep maintenance, unrefreshing sleep, and excessive daytime sleepiness, and it may signify an underlying medical condition.
The PAM-RL ambulatory device for detection of periodic leg movements: a validation study.
- MedicineSleep medicine
- 2005