A genetic risk factor for periodic limb movements in sleep.

  title={A genetic risk factor for periodic limb movements in sleep.},
  author={H. Stef{\'a}nsson and D. Rye and A. Hicks and H. Petursson and A. Ingason and T. Thorgeirsson and Stefan P{\aa}lsson and T. Sigmundsson and A. P. Sigurdsson and Ingibjorg Eiriksdottir and Emilia Soebech and D. Bliwise and J. M. Beck and A. Rosen and S. Waddy and L. M. Trotti and A. Iranzo and M. Thambisetty and Gudmundur A. Hardarson and K. Kristj{\'a}nsson and L. Gudmundsson and U. Thorsteinsdottir and A. Kong and J. Gulcher and D. Gudbjartsson and K. Stef{\'a}nsson},
  journal={The New England journal of medicine},
  volume={357 7},
  • H. Stefánsson, D. Rye, +23 authors K. Stefánsson
  • Published 2007
  • Medicine
  • The New England journal of medicine
  • BACKGROUND The restless legs syndrome (RLS) is a common neurologic disorder characterized by an irresistible urge to move the legs. It is a major cause of sleep disruption. Periodic limb movements in sleep are detectable in most patients with RLS and represent an objective physiological metric. METHODS To search for sequence variants contributing to RLS, we performed a genomewide association study and two replication studies. To minimize phenotypic heterogeneity, we focused on patients with… CONTINUE READING
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