A genetic polymorphism of the alpha2-adrenergic receptor increases autonomic responses to stress.

  title={A genetic polymorphism of the alpha2-adrenergic receptor increases autonomic responses to stress.},
  author={J Clayton Finley and Michael O'Leary and Derin C. Wester and Steven Mackenzie and Neil Shepard and Stephen Farrow and Warren E. Lockette},
  journal={Journal of applied physiology},
  volume={96 6},
We hypothesized that individual differences in autonomic responses to psychological, physiological, or environmental stresses are inherited, and exaggerated autonomic responsiveness may represent an intermediate phenotype that can contribute to the development of essential hypertension in humans over time. alpha(2)-Adrenergic receptors (alpha(2)-ARs), encoded by a gene on chromosome 10, are found in the central nervous system and also mediate release of norepinephrine from the presynaptic nerve… 

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