A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells.

@article{Shamsi2014AGM,
  title={A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells.},
  author={Farnaz Shamsi and Rosanna Parlato and Patrick Collombat and Ahmed Mansouri},
  journal={Cell cycle},
  year={2014},
  volume={13 24},
  pages={
          3948-57
        }
}
The putative induction of adult β-cell regeneration represents a promising approach for the treatment of type 1 diabetes. Toward this ultimate goal, it is essential to develop an inducible model mimicking the long-lasting disease progression. In the current study, we have established a novel β-cell ablation mouse model, in which the β-cell mass progressively declines, as seen in type 1 diabetes. The model is based on the β-cell specific genetic ablation of the transcription initiation factor 1A… CONTINUE READING

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