A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease.

@article{Ramesh2010AGM,
  title={A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease.},
  author={Tennore Ramesh and Alison N Lyon and Ricardo H Pineda and Chunping Wang and Paul M L Janssen and Benjamin D. Canan and Arthur H. M. Burghes and Christine E. Beattie},
  journal={Disease models & mechanisms},
  year={2010},
  volume={3 9-10},
  pages={652-62}
}
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that, for approximately 80% of patients, is fatal within five years of diagnosis. To better understand ALS, animal models have been essential; however, only rodent models of ALS exhibit the major hallmarks of the disease. Here, we report the generation of transgenic zebrafish overexpressing mutant Sod1. The construct used to generate these lines contained the zebrafish sod1 gene and approximately 16 kb of flanking… CONTINUE READING
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