A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster.

@article{Bonini1999AGM,
  title={A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster.},
  author={Nancy M Bonini},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1999},
  volume={354 1386},
  pages={1057-60}
}
  • Nancy M Bonini
  • Published 1999 in
    Philosophical transactions of the Royal Society…
To apply genetics to the problem of human polyglutamine-repeat disease, we recreated polyglutamine-repeat disease in Drosophila melanogaster. To do this, we expressed forms of the human gene encoding spinocerebellar ataxia type 3, also called Machado-Joseph disease (SCA-3/MJD). This gene is responsible for the most common form of human ataxia worldwide. Expression of a normal form of the MJD protein with 27 polyglutamines (MJDtr-Q27) had no phenotype. However, expression of a form of the… CONTINUE READING