A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.

@article{Young1995AGM,
  title={A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.},
  author={Stephen G. Young and Candace M. Cham and Robert E. Pitas and Betty Jane Burri Burri and Andrew Connolly and Laura Flynn and Anuradha S. Pappu and Jinny S. Wong and Robert L. Hamilton and Robert V Farese},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 6},
  pages={2932-46}
}
The formation of chylomicrons by the intestine is important for the absorption of dietary fats and fat-soluble vitamins (e.g., retinol, alpha-tocopherol). Apo B plays an essential structural role in the formation of chylomicrons in the intestine as well as the VLDL in the liver. We have developed genetically modified mice that express apo B in the liver but not in the intestine. By electron microscopy, the enterocytes of these mice lacked nascent chylomicrons in the endoplasmic reticulum and… CONTINUE READING
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Transgenic mice expressing human apoB , 00 and apoB "

  • M. F. Linton, S. G. Young
  • Curr . Opin . Lipidol .
  • 1994

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