A genetic linkage map of the mouse using restriction landmark genomic scanning (RLGS).

@article{Hayashizaki1994AGL,
  title={A genetic linkage map of the mouse using restriction landmark genomic scanning (RLGS).},
  author={Yoshihide Hayashizaki and Shinji Hirotsune and Yuko Okazaki and Hideki Shibata and A Akasako and Masa-aki Muramatsu and Jun Kawai and Tsutomu Hirasawa and Shigeaki Watanabe and Toshihiko Shiroishi},
  journal={Genetics},
  year={1994},
  volume={138 4},
  pages={1207-38}
}
We have developed a multiplex method of genome analysis, restriction landmark genomic scanning (RLGS) that has been used to construct genetic maps in mice. Restriction landmarks are end-labeled restriction fragments of genomic DNA that are separated by using high resolution, two-dimensional gel electrophoresis identifying as many as two thousand landmark loci in a single gel. Variation for several hundred of these loci has been identified between laboratory strains and between these strains and… CONTINUE READING

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