A genetic linkage map of the laboratory rat, Rattus norvegicus

  title={A genetic linkage map of the laboratory rat, Rattus norvegicus},
  author={Howard J. Jacob and Donna M. Brown and Ruth K. Bunker and Mark J. Daly and Victor J. Dzau and Alec Goodman and George Koike and Vladim{\'i}r Křen and Theodore Kurtz and {\AA}ke Lernmark and G{\"o}ran Levan and Yi-pei Mao and Anna Lindskoog Pettersson and Michal Pravenec and Jason S. Simon and Claude Szpirer and Josiane Szpirer and Maria R. Trolliet and E. Samuel Winer and Eric S. Lander},
  journal={Nature Genetics},
We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR × BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the… CONTINUE READING

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